XyliMelts® are a unique type of lozenge. Lozenges are solid oral dosage forms that are designed to dissolve or disintegrate slowly in the mouth*. XyliMelts® are designed adhere within the mouth and formulated to slowly dissolve over a period of hours. They may be used during the day or at night.

There are several factors that influence the amount of time it takes XyliMelts® to dissolve. During the day, XyliMelts® don't last nearly as long as they do at night. this is due to increased mouth movement (talking, eating, drinking), increased saliva flow and frequent swallowing. At night when the mouth is still, XyliMelts® can last twice as long.

Because the rate of dissolution varies amongst individuals, we have gathered evidence to support longevity through numerous clinical studies. Those clinical studies evaluating the benefits of XyliMelts® dissolution profiles support that "XyliMelts® last 1-4 hours during the day and 4-8 hours at night." Some excerpts from efficacy studies are identified below:

Effects of A Novel Disc Formulation on Dry Mouth Symptoms and Enamel Remineralization in Patients With Hyposalivation: An In Vivo Study

Ho J, Firmalino MV, Anbaran AG, Takesh T, Epstein J et al. (2017) An In Vivo Study. Dentistry 7: 411. doi:10.4172/2161-1122.1000411

"Although the subjects reported an inprovement in mouth wetness upon awakening, they also reported that the effects and flavor of the discs last approximately 6 hours while sleeping."

Dental Erosion, GERD, and Salivary Stimulation

Journal of Oral & Dental Health, Jeff Burgess, 2018 Volume 2 Issue 1

"The discs more than doubled saliva production while awake. The discs slowly dissolved over six hours during sleep and the flavor was still sensed upon awakening after 8 hours of sleep."

REDUCING CARIES AND IMPROVING GINGIVAL STATUS WHILE SLEEPING

DENTALPRODUCTSREPORT.COM | April 2017 by Charles R Hoeg, DMD, Shoreham New York, and Jeffrey Burgess, DDS, MSD, Department of Oral Medicine, University of Washington School of Dental Medicine, USA (Retired)

"We present a case where an adult patient used each night while sleeping two OraCoat XyliMelts adhering discs, each disc releasing one-half gram of xylitol over 4 to 8 hours, and thereby eliminated previously ongoing cervical caries." "OraCoat XyliMelts adhering discs are designed to dissolve slowly and last up to 8 hours while sleeping. OraCoat XyliMelts have been specifically assessed for use during sleep. Subjects reported that they still tasted xylitol in their mouths upon awakening after 8 hours of sleep. During the day, XyliMelts discs last 1 to 4 hours, depending in part on location in the mouth, rate of salivation, and amount of mouth movement."

XyliMelts time-release adhering discs for night-time oral dryness

Burgess J, Lee P. XyliMelts time-release adhering discs for night-time oral dryness. Int J Dent Hyg. 2012 May;10(2):118-21. doi: 10.1111/j.1601-5037.2011.00532.x. Epub 2011 Oct 31. PMID: 22040224.

"Dry mouth can be caused by medicatoin, CPAP use, radiation treatment and a variety of connective tissue diseases, with the prevalence increasing with age. In most individuals, daytime dryness is easily managed. However, except for a new product tested in this study, there is no product lasting longer than an hour that can be used at night to reduce the perception of oral dryness while sleeping."

Amazon Customer Feedback

September, 2025 This product currently Rates 4.5 out of 5 stars with 21,948 global ratings

"Customers find this dry mouth product effective, noting it works all night and keeps them from waking up with a dry mouth. The product receives positive feedback for its mild flavor, quality, and ability to stick well to gums, with one customer mentioning it's perfect for CPAP users. Customers appreciate its long-lasting properties, with one review specifically noting it lasts about 7-8 hours, while others report solid 4-hour blocks of sleep."

*United States Pharmacopeia, USPNF 2025 Issue 2